Biotransformation, a Promising Technology for Anti-cancer Drug Development

Abstract

With the high morbidity and mortality caused by cancer, finding new and more effective anti-cancer drugs isvery urgent. In current research, biotransformation plays a vital role in the research and development of cancerdrugs and has obtained some achievements. In this review, we have summarized four applications as follows:to exploit novel anti-cancer drugs, to improve existing anti-cancer drugs, to broaden limited anti-cancer drugresources and to investigate correlative mechanisms. Three different groups of important anti-cancer compoundswere assessed to clarify the current practical applications of biotransformation in the development of anti-cancerdrugs.

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