Comparison of Population Based Cancer Incidence Rates among Circassians, Chechans and Arabs in Jordan (1996-2005)


Background: Cancer is a complex disease caused by multiple factors, both genetic and environmental. It is amajor health concern worldwide, in the Middle East and in Jordan specifically and the fourth most common killerin the Middle East. Hypothesis: The relative genetic homogeneity of the Circassian and Chechan populations inJordan results in incidences of cancer that differ from the general Jordanian population, who are mostly Arabs.Materials and
Methods: National Cancer Registry data were obtained for the years 1996-2005 The Chechenand Circassian cancer cases were identified and cancer registry data were divided into three populations. Cruderates were calculated based on the number of cancer cases and estimated populations.
Results: Breast canceris the most common cancer type constituting about one third of female cancers in all three populations. Highercrude rates are observed in the Circassian and Chechen populations than in the Arab Jordanian population.The rate ratios (95%CI) in Circassians and Chechens with respect to the Arab Jordanian population are 2.1(1.48, 2.72) and 1.81 (1.16, 2.85), respectively. Lung cancer is the most common cancer in male Arab Jordaniansand Chechens with crude rates of 4.2 and 8.0 per 100,000 respectively. The male to female ratio in these twopopulations in respective order are 5:1 and 7:1. The lung cancer crude rate in Circassians is 6.5 per 100,000 with amale to female ratio of only 1.6:1. The colorectal cancer crude rates in Arab Jordanians and Chechens are similarat 6.2 and 6.0 per 100,000, respectively, while that in Circassians is twice as high.
Conclusions: Considerableethnic variation exists for cancer incidence rates in Jordan. The included inbred and selected populations offeran ideal situation for investigating genetic factors involved in various cancer types.