Role of DNA Repair-related Gene Polymorphisms in Susceptibility to Risk of Prostate Cancer

Aim: We assessed the association between genetic variants of XPG, XPA, XPD, CSB, XPC and CCNH inthe nucleotide excision repair (NER) pathway and risk of prostate cancer.
Methods: We genotyped the XPG,XPA, XPD, CSB, XPC and CCNH polymorphisms by a 384-well plate format on the MassARRAY® platform.Multivariate logistical regression analysis was used to assess the associations between the six gene polymorphismsand risk of prostate cancer.
Results: Individuals carrying the XPG rs229614 TT (OR=2.01, 95%CI=1.35-3.27)genotype and T allele (OR=1.73, 95%CI=1.37-2.57) were moderately significantly associated with a higher riskof prostate cancer. Subjects with XPD rs13181 G allele had a marginally increased risk of prostate cancer, withadjusted OR(95%CI) of 1.53 (1.04-2.37). Moreover, individuals carrying with CSB rs2228526 GG genotype(OR=2.05, 95% CI=1.23-3.52) and G allele (OR=1.56, 95%CI=1.17-2.05) were associated with a higher increasedrisk of prostate cancer. The combination genotype of XPG rs2296147 T and CSB rs2228526 G allele hadaccumulative effect on the risk of this cancer, with an OR (95% CI) of 2.23(1.37-3.59).
Conclusions: Our studyindicates that XPG rs2296147 and CSB rs2228526 polymorphisms are significantly associated with increasedrisk of prostate cancer, and that combination of XPG rs2296147 T allele and CSB rs2228526 G allele is stronglyassociated with an increased risk.