Metaplastic breast cancer (MBC) is a rare type of breast carcinoma, characterized by various combinationsof mesenchymal, adenocarcinoma and other epithelial components. MBC often manifests as a large mass, withlow axillary lymph node involvement and poor prognosis. Knowledge and treatment patterns about MBCdemographics, presentation and tumor characteristics are very limited. In clinical practice, MBC is usuallytreated based on the guidelines developed for infiltrating ductal carcinoma (IDC). The ideal treatment paradigmfor MBC is unknown due to its low incidence and pathological variability, so potential predictors of treatmentefficacy need to be explored. This review summarizes the current models and strategies for MBC according tothe published literature.