Clinical Significance of Combined Detection of Serum Tumor Markers in Diagnosis of Patients with Ovarian Cancer


Objective: To explore the predictive value of tumor markers, including cancer antigen 72-4 (CA72-4), cancerantigen 15-3 (CA15-3) and cancer antigen 125 (CA125), in single or combined detection, for the diagnosis ofovarian cancer.
Methods: 120 patients diagnosed with ovarian cancer from August 2011 to March 2013 and80 patients diagnosed with benign ovarian tumors were enrolled in this test, along with 50 health examinationwomen randomly selected from the database as controls. Serum levels of CA72-4, CA15-3 and CA125 in this studywere determined by electrochemiluminescence (ECL).
Results: Serum levels of CA72-4, CA15-3 and CA125 inovarian cancer were higher than those in healthy group and benign group (P<0.01).The sensitivity of combineddetection of those three tumor markers for diagnosis of ovarian cancer was obviously higher than with singledetection with each marker (P<0.01).
Conclusions: CA72-4, CA15-3 and CA125 could be a good combination inthe diagnosis of ovarian cancer. Patients whose tumor markers continue to increase should be highly suspectedof malignancy.