Expression of EGFR and p53 in Head and Neck Tumors among Sudanese Patients


Background: The aim of this study was to assess EGFR and p53 expression in head and neck tumors amongSudanese patients using immunohistochemistry. Materials and
Methods: A retrospective descriptive studywas performed on 150 samples from patients diagnosed with HNCs as well as 50 from individuals with benignhead and neck tumors. EGFR and p53 expression was assessed using immunohistochemistry (IHC).
Results:EGFR was expressed in 126/150 (84%) of HNCS and 6/50 (12%) benign head and neck tumors where as p53was expressed in 29/150 (19.3%) of HNCs and 2/50 (4%) of benign head and neck tumors, with significanceat p values of 0.001 and 0.009 respectively.
Conclusions: There is a significant association between EGFR, P53expression and head and neck cancers among Sudanese patients.