Background: Genetic polymorphisms of TP63 have been suggested to influence susceptibility to lungadenocarcinoma development in East Asian populations. This study aimed to investigate the relationship betweencommon polymorphisms in the TP63 gene and the risk of lung adenocarcinoma, as well as interactions of thepolymorphisms with environmental risk factors in Chinese non-smoking females.
Methods: A case-control studyof 260 cases and 318 controls was conducted. Data concerning demographic and risk factors were obtained foreach subject. The genetic polymorphisms were determined by Taqman real-time PCR and statistical analyseswere performed using SPSS software.
Results: For 10937405, carriers of the CT genotype or at least one T allele(CT/TT) had lower risks of lung adenocarcinoma compared with the homozygous wild CC genotype in Chinesenonsmoking females (adjusted ORs were 0.68 and 0.69, 95%CIs were 0.48-0.97 and 0.50-0.97, P values were0.033 and 0.030, respectively). Allele comparison showed that the T allele of rs10937405 was associated with adecreased risk of lung adenocarcinoma with an OR of 0.78 (95%CI=0.60-1.01, P=0.059). Our results showed thatexposure to cooking oil fumes was associated with increased risk of lung adenocarcinoma in Chinese nonsmokingfemales (adjusted OR=1.58, 95%CI=1.11-2.25, P=0.011). However, we did not observe a significant interaction ofcooking oil fumes and TP63 polymorphisms.
Conclusion: TP63 polymorphism might be a genetic susceptibilityfactor for lung adenocarcinoma in Chinese non-smoking females, but no significant interaction was found withcooking oil fume exposure.