• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Asian Pacific Journal of Cancer Prevention
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 20 (2019)
Volume Volume 19 (2018)
Volume Volume 18 (2017)
Volume Volume 17 (2016)
Volume Volume 16 (2015)
Volume Volume 15 (2014)
Volume Volume 14 (2013)
Issue Issue 12
Issue Issue 11
Issue Issue 10
Issue Issue 9
Issue Issue 8
Issue Issue 7
Issue Issue 6
Issue Issue 5
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 13 (2012)
Volume Volume 12 (2011)
Volume Volume 11 (2010)
Volume Volume 10 (2009)
Volume Volume 9 (2008)
Volume Volume 8 (2007)
Volume Volume 7 (2006)
Volume Volume 6 (2005)
Volume Volume 5 (2004)
Volume Volume 4 (2003)
Volume Volume 3 (2002)
Volume Volume 2 (2001)
Volume Volume 1 (2000)
(2013). Connections Between Various Trigger Factors and the RIP1/RIP3 Signaling Pathway Involved in Necroptosis. Asian Pacific Journal of Cancer Prevention, 14(12), 7069-7074.
. "Connections Between Various Trigger Factors and the RIP1/RIP3 Signaling Pathway Involved in Necroptosis". Asian Pacific Journal of Cancer Prevention, 14, 12, 2013, 7069-7074.
(2013). 'Connections Between Various Trigger Factors and the RIP1/RIP3 Signaling Pathway Involved in Necroptosis', Asian Pacific Journal of Cancer Prevention, 14(12), pp. 7069-7074.
Connections Between Various Trigger Factors and the RIP1/RIP3 Signaling Pathway Involved in Necroptosis. Asian Pacific Journal of Cancer Prevention, 2013; 14(12): 7069-7074.

Connections Between Various Trigger Factors and the RIP1/RIP3 Signaling Pathway Involved in Necroptosis

Article 4, Volume 14, Issue 12, December 2013, Page 7069-7074  XML PDF (364.33 K)
Abstract
Programmed cell death is a basic cellular process that is critical to maintaining tissue homeostasis. In contrastto apoptosis, necrosis was previously regarded as an unregulated and uncontrollable process. However, as researchhas progressed, necrosis, also known as necroptosis or programmed necrosis, is drawing increasing attention,not least becasu of its possible impications for cancer research. Necroptosis exhibits a unique signaling pathwaythat requires the involvement of receptor interaction protein kinases 1 and 3 (RIP1 and RIP3), mixed lineagekinase domain-like (MLKL), and phosphoglycerate mutase 5 (PGAM5) and can be specifically inhibited bynecrostatins. Not only does necroptosis serve as a backup cell death program when apoptosis is inhibited, but itis now recognized to play a pivotal role in regulating various physiological processes and the pathogenesis of avariety of human diseases such as ischemic brain injury, immune system disorders and cancer. The control ofnecroptosis by various defined trigger factors and signaling pathways now offers the opportunity to target thiscellular process for therapeutic purposes. The purpose of this paper is to review current findings concerning theconnections between various trigger factors and the RIP1/RIP3 signaling pathway as it relates to necroptosis.
Keywords
Necroptosis; TNFR; Fas; TRAILR; RIP1-RIP3 necrosome; MLKL complex
Statistics
Article View: 629
PDF Download: 572
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

 



 

Journal Management System. Designed by sinaweb.