Clinical Profile, Treatment and Survival Outcome of Testicular Tumors: A Pakistani Perspective


Background: Testicular cancer management is considered a marvel of modern science with excellenttreatment results. Pakistan has a distinct ethnic variation and geographic distribution but data regardingclinical presentation of testicular tumors and their management is under reported. The objective of this studywas to determine clinical profile, treatment modalities and survival outcome of testicular tumors in the Pakistanipopulation. Materials and
Methods: A retrospective review of patients who received treatment for testicularcancer at Shaukat Khanum Cancer Hospital from January 2009 to December 2012 was performed. Patientdemographics, clinical features at presentation and treatment modalities were assessed. For categorical variableschi square test was used. Survival was calculated using Kaplan Meier survival curves and Log rank test wasemployed to determine significance.
Results: The most common tumor was mixed germ cell tumor in 49%patients. For all tumor variants except seminoma, stage III was the most common clinical stage at presentation.Majority of patients with non seminomatous germ cell tumors presented in the15-30 year age group as comparedto seminoma which was most prevalent in the 30-40 year age group. Orchiectomy followed by chemotherapywas the most common treatment modality in 80% patients. Expected 5 year survival for seminomas and nonseminomatousgerm cell tumors was 96% and 90% respectively which was not significantly different (p=0.2).
Conclusions: Despite a distinct clinical profile of testicular tumors in Pakistani population, survival is comparablewith published reports.