Association between the Metabolic Syndrome and High Tumor Grade and Stage of Primary Urothelial Cell Carcinoma of the Bladder


Purpose: To compare histopathologic findings of patients who underwent transurethral resection of abladder tumor (TUR-B) between groups with and without the metabolic syndrome. Materials and
Methods:We retrospectively analyzed data of 535 patients who underwent TUR-B in our department between October2005 and March 2011. All patients had primary urethelial cell carcinoma (UCB). Histologic stage, grade, thepresence of hypertension, diabetes mellitus, body mass index (BMI), waist circumference, HDL and trigliseridelevels were evaluated. The TNM classification was used, with Ta tumor accepted as lower stage and T1 andT2 tumors as higher stage bladder cancers. Also, the pathological grading adopted by the 2004 World HealthOrganization grading system were applied. Non-invasive papillary urothelial neoplasms of low malignantpotential were regarded as low grade.
Results: Among the total of 509 patients analyzed in our study, there were439 males (86.2%) and 70 females (13.8%). Metabolic syndrome was significantly associated with high histologicgrade, and high pathologic stage (p<0.001).
Conclusions: The patients with metabolic syndrome were found tohave statistically significant higher T stage and grade of bladder cancer. Further studies with more patients areneeded to confirm our study.