The objective of this study was to investigate the recent incidence and mortality trends for breast cancer inMexican females. Data between 2000 and 2010 from the Department of Epidemiology of the Ministry of Health,and International Agency for Research on Cancer (IARC) were analyzed. Age-standardized rates (ASRs) andannual percent changes (APCs) were calculated. The absolute incidence and mortality rates of breast cancerincreased: 3,726 and 4,615 in 2000 to 8,545 and 4,966 in 2010, respectively. Incidence increased over time in allage groups tested, the 60-64 age group had the highest ASR (57.4 per 100,000 women in 2010), while the 20-44age group had the lowest ASR (12.3 in 2010). The results show that incidence of breast cancer has increased inMexico during last one decade, especially among older women, while the downturn observed in mortality mainlyreflects improved survival as a result of earlier diagnosis and better cancer treatment.