Background: The overall prognosis for cancers of unknown primary (CUP) is poor, median overall survival(OS) being 6-12 months. We evaluated our multicentric retrospective experience for CUP administered docetaxeland cisplatin combination therapy. Materials and
Methods: A total of 29 patients that were pathologicallyconfirmed subtypes of CUP were included in the study. The combination of docetaxel (75 mg/m2, day 1) andcisplatin (75 mg/m2, day 1) was performed as a first line regimen every 21 days.
Results: The median age was 51(range: 27-68). Some 17 patients had multimetastatic disease on the inital diagnosis. Histopathological diagnoseswere well-moderate differentiated adenocarcinoma (51.7%), undifferentiated carcinoma (27.6%), squamouscell cancer (13.8%), mucoepidermoid carcinoma (3.4%) and neuroendocrine differentiated carcinoma (3.4%).Median number of cycles was 3 (range: 1-6). Objective response rate was 37.9% and clinical benefit was 58.6%.Median progression free survival (PFS) and overall survival (OS) were 6 months (range: 4.3-7.7 months) and 16months (range: 8.1-30.9 months), respectively. Fourteen patients (60.8%) were treated in a second line setting.There was no treatment related death. Most common toxicities were nausia-vomiting (44.6%) and fatigue (34.7%),serious cases (grade 3/4) suffering nausia-vomiting (10.3%), neutropenia (13.8%) and febrile neutropenia (n=1).
Conclusion: The combination of cisplatin and docetaxel is an effective regimen for selected patients with CUP.