Purpose: To evaluate the survival outcome of early stage endometrioid adenocarcinoma of the endometriumwith risk factors for locoregional recurrence treated with combined pelvic external beam radiotherapy (EBRT)and vaginal brachytherapy (VBT) after comprehensive surgery. Materials and
Methods: Post-operativeradiotherapy by pelvic EBRT and VBT for early stage endometrioid endometrial carcinoma resulted in excellentpelvic control with acceptable complications. This study showed no significant relationships between age, stage,histologic grade and LVSI and overall survival rate.
Results: The 5-year overall survival rate (OS) of early stageendometrioid type of endometrial carcinoma was 85.7%. Acute toxicity occurred in 38.1% of the patients, all ofwhom were grade 1 or 2. Total late toxicity developed in 42.9% of study group, in which 36.99% of them weregrade 1-2 and 4.76% were grade 3-4.
Conclusions: Post-operative radiotherapy by pelvic EBRT and VBT isacceptable for early stage endometrioid endometrial carcinoma, independent of age, stage, histologic grade andLVSI.