Clinicopathologic and Diagnostic Significance of p53 Protein Expression in Papillary Thyroid Carcinoma


Background: p53 protein expression has been detected immunohistochemically in papillary thyroidcarcinoma(PTC). We investigated the relations between its expression and clinicopathologic features and itssignificance as a diagnostic marker. Materials and
Methods: We compared and evaluated 93 patients in whomthyroidectomy with lymph node dissection had been performed to treat PTC for clinicopathologic significanceand 102 patients with 23 papillary thyroid overt carcinomas (POC), 57 papillary thyroid microcarcinomas(PMC),5 follicular adenomas (FA), 5 Hashimoto’s thyroiditis (HT) and 12 nodular hyperplasias (NH) for significanceas a diagnostic marker. Expression of p53 protein was evaluated immunohistochemically in sections of paraffinembeddedtissue.
Results: Statistical analysis showed significantly different expression of p53 in PTC versusother benign thyroid lesions (BTL).The diagnostic sensitivity and specificity were 85.0% and 72.7%, respectively.Overexpression of p53 protein was observed in 44 of the 93 PTC cases (47.3%), but no significant correlationbetween p53 protein overexpression and clinicopathologic features (age, size, multiplicity, lymph node metastasis,extrathyroidal extension and vascular invasion) was noted.
Conclusions: p53 is valuable to distinguish PTC fromother BTL, but there is no correlation between p53 protein overexpression and clinicopathologic features.