Anthocyanins: Targeting of Signaling Networks in Cancer Cells


It is becoming progressively more understandable that phytochemicals derived from edible plants haveshown potential in modelling their interactions with their target proteins. Rapidly accumulating in-vitroand in- vivo evidence indicates that anthocyanins have anticancer activity in rodent models of cancer. Moreintriguingly, evaluation of bilberry anthocyanins as chemopreventive agents in twenty-five colorectal cancerpatients has opened new window of opportunity in translating the findings from laboratory to clinic. Confluenceof information suggests that anthocyanins treated cancer cells reveal up-regulation of tumor suppressor genes.There is a successive increase in the research-work in nutrigenomics and evidence has started to shed lighton intracellular-signaling cascades as common molecular targets for anthocyanins. In this review we bring tol imelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways.