Risk Factors for Appendiceal Metastasis with Epithelial Ovarian Cancer


Purpose: To investigate the risk factors for appendiceal metastasis of epithelial ovarian cancer and comparefindings with the previous studies. Materials and
Methods: One hundred and thirty-four patients withepithelial ovarian cancer were assessed in this study. All of them had undergone a surgical procedure includingappendectomy. Of these, 21 (15.7%) patients who had appendiceal metastasis were analyzed as the case groupand the patients with no metastasis were the controls, compared according to stage, grade, histology of tumor,preoperative Ca125 levels, presence of ascites, peritoneal cytology, diameter and site of tumor considered asrisk factors.
Results: We found statistically significant differences between the groups in terms of stage, grade,right-sided tumor location, presence of ascites, diameter of tumor≥10 cm and positive peritoneal cytology(p<0.05). In the logistic regression model, stage, grade, presence of ascites, right-sided location and diameter oftumor were independent risk factors. ROC curve analysis showed that stage, grade and diameter of the tumorwere discriminative factors for appendiceal metastasis.
Conclusions: In epithelial ovarian cancer, stage, grade,presence of ascites, right-sided location and large tumor size have importance for estimation of risk of appendicealmetastasis. As we compare our findings with previous studies, there is no definite recommendation for the riskfactors of appendiceal metastasis in epithelial ovarian cancer and more studies are needed.