Endometrial Adenocarcinoma: Clinicopathologic and Survival Characteristics in Yazd, Iran


Background: Endometrial adenocarcinoma is the most common gynecological cancer in the Western worldand its incidence appears to be rising. However, population-based studies on endometrial cancer providingsurvival estimates by age, histology, and stage in Asia have been sparse. The aim of this study was to evaluate theclinicopathological data and survival for patients with endometrial adenocarcinoma treated at three institutions inYazd, Iran. Materials and
Methods: Medical and anatomicopathological records at the Department of Pathologyand Radiotherapy of the Shahid Sadoughi University of Medical Sciences and Madar private hospital, between2005 and 2012 were reviewed. All cases of endometrial adenocarcinoma were included. The Kaplan-Maiermethod was used for survival analysis and Cox proportional hazards model for multiple regression analysis.
Results: The study included 84 patients. Stages I, II, III, and IV were identified in 65.4%, 21.5%, 11.9% and1.2%, respectively. Disease-free survival rate was 73.9±3.77 months (95% confidence interval, 64.51-83.22months) and relapse occurred in 12.3% of the patients. The overall survival rate was 78. 2±3.65 months (95%confidence interval, 71.0-85.3 months). A multivariate analysis revealed that stage and grade were associatedwith overall survival.
Conclusions: In this survival analysis of patients with endometrial cancer, we found thatthe prognosis of endometrial cancer was fair but strongly varied by stage and grade, and moderately varied byhistology and age.