Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix


Background: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervicalcarcinoma and to investigate a possible correlation of histology with prognosis. Materials and
Methods: Twohundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO(International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the RadiationOncology Clinic of GH Okmeydanı Training and Research Hospital between January 1996 and December 2006were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Diseasefreesurvival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differenceswere compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was usedto adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI).
Results:There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrialinvasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-yearOS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p> 0.05).Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resectionmargin status for OS (p=0.008, p=0.002, respectively).
Conclusions: Prognosis of FIGO stage IA-IIB cervicalcancer patients was found to be the same for those with adenocarcinoma and SCC.