E-Selectin S128R Polymorphism is Associated with Cancer Risk: a Meta-analysis


Background: Genetic factors have been shown to play an important role in the development of cancers.However, individual studies may fail to completely demonstrate complicated genetic relationships because ofsmall sample size. Therefore, we performed a meta-analysis to evaluate the association of E-selectin Ser128Arg(S128R) with cancer risk. Materials and
Methods: A literature search in PubMed, Embase, Web of Science,Science Direct, SpringerLink, EBSCO, Wanfang, and Chinese National Knowledge Infrastructure databaseswas carried out to identify studies of the association between E-selectin S128R polymorphism and cancer risk.The odds ratio (OR) with 95% confidence intervals (95%CIs) were used to assess the strength of association.
Results: A total of eight studies involving 1,675 cancer cases and 2,285 controls were included in the meta-analysis.In overall populations, S128R polymorphism seemed to be associated with cancer risk (Arg allele vs Ser allele:OR=1.65, 95%CI =1.33-2.04, p<0.01; Arg/Arg+Arg/Ser vs Ser/Ser: OR=1.87, 95%CI =1.48-2.36, p<0.01; Arg/Servs Ser/Ser: OR=1.80, 95%CI =1.51-2.14, p<0.01). Similarly, subgroup analysis by ethnicity and source of controlalso revealed that this polymorphism was related to cancer risk.
Conclusions: Our meta-analysis revealed thatthere was association between the E-selectin S128R polymorphism and the risk of cancer. Further large andwell-designed studies are needed to confirm this association.