Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey


Background: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and
Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period betweenJanuary 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the InternationalFederation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agentchemotherapy, surgical interventions and prognosis were evaluated.
Results: From 2003-2013, there were 1,173,235 deliveriesand 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluateddata of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was presentfor 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66)and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7(1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients.
Conclusions: Because of the differencesbetween countries, it is important to provide national registration systems and special clinics for the accurate diagnosis andtreatment of GTN.