The Metabolic Syndrome is Associated with More Aggressive Prostate Cancer


Purpose: The aim of this study was to analyze any association between the metabolic syndrome (MetS) andrisk of prostate cancer (PCa) and cancer grade among men undergoing radical prostatectomy for PCa. Materialsand
Methods: 50 patients with MetS and 50 patients without MetS who undervent radical prostatectomy (RP)were included in the study. Age at biopsy, height, weight, digital rectal examination (DRE), pre-biopsy PSAlevels, prostate volume, histopathologic diagnosis after surgery and gleason scores were collected data from allpatients. Histologic material obtained at biopsy was given a Gleason score; tumours with a Gleason score ≥7were considered high grade and <7 were considered low grade.
Results: The mean age at the time of biopsy was63.7±5.94 in patients with MetS and 61.6±6.14 in patients without MetS. Men with MetS had significantly lowerPSA levels (p=0.01) (7.21±2.74 and 8.81±2.72, respectively). Also, the men with MetS had higher RP tumor grade(p=0.04).
Conclusions: Men with MetS undergoing RP have lower PSA levels and have significantly higher gradePCa. We must be careful for screening PCa in patients with MetS. Although the patients had lower PSA levels,they may have high grade disease.