Predictive Role of the Neutrophil Lymphocyte Ratio for Invasion with Gestational Trophoblastic Disease

Purpose: The objective of this study was to assess the predictive role of the neutrophil/lymphocyte ratio (NLR)for invasion of gestational trophoblastic disease (GTD). Materials and
Methods: A retrospective analysis wasconducted on 127 women who were managed at our clinic for GTD. Of all patients, 8 showed invasion accordingto histological examination. The clinical parameters of patients with invasive GTD (Group 1; n=8) were comparedwith patients who showed no invasion (Group 2; n=119). All underwent a prior uterine evacuation and followed upby regular assessment of β-hCG titers.
Results: Demographic and obstetric history and pre-evacuation hCG levelsof the patients showed no statistically significantly difference between the groups (p>0.05). The mean gestationalweeks (GW), size of the GTD and NLR levels were statistically significantly higher in the invasive GTD group(p<0.05). Correlations between invasion and gestational weeks, size of GTD, post-evacuation chemotherapy andNLR were evident. ROC curve analysis demonstrated that GW, size of GTD and NLR may be discriminativeparameters in predicting invasion of GTD.
Conclusions: To the best of our knowledge, this is the first studyevaluating the predictive role of NLR in invasion of GTD. In conclusion ,we think that pretreatment NLR canbe used as a biomarker of invasion in GTD.