Cancer is the most deadly disease that causes the serious health problems, physical disabilities, mortalities,and morbidities around the world. It is the second leading cause of death all over the world. Although greatadvancement have been made in the treatment of cancer progression, still significant deficiencies and room forimprovement remain. Chemotherapy produced a number of undesired and toxic side effects. Natural therapies,such as the use of plant-derived products in the treatment of cancer, may reduce adverse and toxic side effects.However, many plants exist that have shown very promising anticancer activities in vitro and in vivo but theiractive anticancer principle have yet to be evaluated. Combined efforts of botanist, pharmacologist and chemistsare required to find new lead anticancer constituent to fight disease. This review will help researchers in thefinding of new bioactive molecules as it will focus on various plants evaluated for anticancer properties in vitroand in vivo.