Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening toolsfor detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GChas become a major overall initiative. RNA-interference (RNAi) is an innovative technique that can significantlyregulate the expression of oncogenes involved in gastric carcinogenesis, thus constituting a promising epigeneticapproach to GC therapy. This review presents recent advances concerning the promising biomolecular mechanismof RNAi for GC treatment.
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