Human Papillomavirus Genotypes Profile in Cervical Cancer Patients at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia


Background: As in other developing countries, cervical cancer is the most frequent gynecologic malignancy inIndonesia. Persistent high risk genotypes of human papillomavirus (HPV) that infect the cervical tissue have beenestablished as the etiology of cervical cancer. This study aimed to explore the profile of cervical cancer patients andthe infected HPV genotypes at Dr. Hasan Sadikin General Hospital-Bandung. Materials and
Methods: During theyear 2010, 554 cervical cancer patients were registered. In a subset of the patients during July – November 2010,40 randomized fresh biopsies were tested for HPV genotype after obtained informed consent. The distributionof HPV genotypes and the association to risk factors were analysed.
Results: The result showed that 62.5% ofthe tested biopsies were infected by multiple HPV infections, with HPV-16 found in most of the cervical cancerpatients (90%). Marriage at age younger than 16 years old was statistically significant in relation to multipleHPV infection (p=0.003), but not parity more than three times (p=0.59).
Conclusions: Although high paritiy inour study was not associated with multiple HPV infection, good family planning programs and reproductivehealth education need to be emphasized in Indonesia as high parity and marriage at young age might increasethe chance of cervical cancer development.