Prognostic Value of Caveolin-1 Expression in Gastric Cancer: a Meta-analysis


The relationship between caveolin-1 (Cav-1) and clinicopathological characteristics of gastric cancer iscontroversial, although Cav-1 plays an important role in tumor metastasis. To evaluate the clinicopathologicaland prognostic value of expression in patients with gastric cancer, a meta-analysis was performed to investigatethe impact on clinicopathological parameters and prognosis in gastric cancer cases. Studies assessing theseparameters for Cav-1 in gastric cancer were identified up to June 2014. Finally, a total of six studies met theinclusion criteria. Our combined results showed that Cav-1 expression was significantly associated with theLauren classification (pooled OR=0.603, 95% CI: 0.381-0.953, P=0.030). Furthermore, we found that Cav-1expression predicted a better overall survival in gastric cancer patients (pooled OR=0.590, 95% CI: 0.360-0.970,P=0.038, fixed-effect). In conclusion, the overall data of the present meta analysis showed that Cav-1 expressionwas not correlated with clinicopathological features except for the Lauren classification. Simultaneously, Cav-1overexpression predicted a better overall survival in gastric cancer. Cav-1 expression in tumors is a candidatepositive prognostic biomarker for gastric cancer patients.