Folate Pathway Gene MTHFR C677T Polymorphism and Risk of Lung Cancer in Asian Populations


Background: Previous studies concerning the association between the 5,10-methylenetetrahydrofolatereductase (MTHFR) C677T gene polymorphism with lung cancer in Asian populations have provided inconclusivefindings. Aim: A meta-analysis was performed to investigate a more reliable association between MTHFR C677Tpolymorphism and lung cancer in Asians. Materials and
Methods: A comprehensive search was conducted toidentify all case-control studies of MTHFR polymorphisms and lung cancer in Asia, using odds ratios (ORs) with95% confidence intervals (CIs) to assess the strength of any association.
Results: Meta-analysis results suggestedthat the MTHFR C677T polymorphism contributed to an increased lung cancer risk in Asian populations (forT vs C: OR=1.11, 95%CI=1.0-1.23; for CT vs CC: OR= 1.1, 95%CI= 0.95-1.2 ; for TT+CT vs CC: OR=1.13,95%CI=1.0-1.30; for TT vs CC: OR=1.25, 95%CI=1.01-1.30; for TT vs CT+CC: OR=1.16, 95%CI=1.0-1.36).
Conclusions: MTHFR C677T polymorphism is significantly associated with lung cancer in Asians.