To investigate the value of expression of annexin A2, microvessel density (MVD) and CD105 in pancreaticductal adenocarcinoma (PDAC) tissues and adjacent normal tissues, immunohistochemical staining was used.The positive expression rate of Annexin A2 and the MVD in pancreatic ductal adenocarcinoma tissues washigher than that in in adjacent normal tissues (p<0.005). Expression of Annexin A2 and MVD correlated withhistological grade (p<0.05). MVD of cancers in TNM stage Ⅱb was higher than that in TNM stageⅠ~Ⅱa (p<0.026).Cancerous tissues with Annexin A2 staining grade 3+ had lower MVD than the tissues with the other AnnexinA2 staining grade (p<0.05). Patients with high MVD had worse prognosis. However , our study did not confirmAnnexin A2 was an independent risk factor for patients with PDAC. We confirmed MVD labeled by CD105 wasan independent risk factor for patients with PDAC and had moderate predictive value of prognosis.