Thyroid Nodules with Atypia or Follicular Lesions of Undetermined Significance (AUS/FLUS): Analysis of Variables Associated with Outcome


Background: The Bethesda System for Reporting Thyroid Cytopathology is one of the main classificationsystems for thyroid nodules. It expects that 7% of all fine needle aspiration biopsies will be reported as atypiaor follicular lesions of undetermined significance, and 5-15% of these undetermined nodules are malignant. Ourstudy is a retrospective analysis of variables that may be associated with outcome in patients with indeterminatethyroid nodules. Materials and
Methods: Patients who underwent thyroidectomy in our institution between 2010and 2014 were retrieved from the institutional records database. Patient demographics and medical historieswere recorded. All ultrasonography reports were examined for nodule features and biochemical blood levels,hormone levels and complete blood counts were recorded.
Results: A total of 103 patient cytopathology reportswere regarded as belonging to the undetermined category. Some 35% of patients had malignant nodules. Medianpreoperative red cell distribution width (RDW) level was 13.6 inthe benign group, while it was 14.3 in patientswith malignancy, demonstrating a significant correlation (p=0.003). Only calcification presence was significantlydifferent between benign and malignant groups on ultrasonography (p=0.034).
Conclusions: Ultrasonography isone of the primary tools for this matter. RDW levels may become another promising tool to predict malignancy.