The Polymorphism of Hypoxia-inducible Factor-1a Gene in Endometrial Cancer


Background: Endometral carcinoma is the most common malignant tumor of the female genital tract andthe fourth most common cancer in women after breast, colorectal and lung cancers Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia HIF-1 plays important rolesin the development and progression of cancer through activation of various genes that are involved in crucialaspects of cancer biology, including angiogenesis, energy metabolism, vasomotor function, erythropoiesis, andcell survival. In this study, we aimed to investigate the association between HIF-1 1772 C/T polymorphisms andendometrial cancer. Materials and
Methods: 75 patients with endometrial carcinoma and 75 patients whoseunderwent hysterectomy for non tumoral indication selected for evaluation of HIF-1 1772 C/T polymorphismsby PCR-RFLP and sequencing.
Results: For the 1772 C/T polymorphism, the analysis showed that the T alleleand genotype TT were significantly associated with endometrial cancer risk.
Conclusions: Our results suggestthat the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.