Background: Aberrations in gene methylation patterns play important roles in gliomagenesis. However,whether the ALDH1A3 promoter methylation is related to prognoses of primary glioblastomas (GBMs) in WesternChina remains unclear. Materials and Methods: Methylation levels of ALDH1A3 CpG island in 36 GBMs wereidentified by pyrophosphate sequencing, while ALDH1A3 expression was assessed with matched paraffin sectionimmunohistochemistry. Survival curves were analysed by Kaplan-Meier. Results: The hypermethylation statusof ALDH1A3 promoter predicted a better prognosis accompanied with low expression of ALDH1A3 protein. Conclusions: Our results indicate ALDH1A3 promoter methylation correlates with prognosis in primary GBMs.
(2015). Prognostic Value of ALDH1A3 Promoter Methylation in Gliob;astoma: A Single Center Experience in Western China. Asian Pacific Journal of Cancer Prevention, 16(2), 591-594.
MLA
. "Prognostic Value of ALDH1A3 Promoter Methylation in Gliob;astoma: A Single Center Experience in Western China". Asian Pacific Journal of Cancer Prevention, 16, 2, 2015, 591-594.
HARVARD
(2015). 'Prognostic Value of ALDH1A3 Promoter Methylation in Gliob;astoma: A Single Center Experience in Western China', Asian Pacific Journal of Cancer Prevention, 16(2), pp. 591-594.
VANCOUVER
Prognostic Value of ALDH1A3 Promoter Methylation in Gliob;astoma: A Single Center Experience in Western China. Asian Pacific Journal of Cancer Prevention, 2015; 16(2): 591-594.
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