Expression of Cox-2 and Bcl-2 in Paget’s Disease of the Breast


Background: Paget’s disease (PD) is a rare form of intraepithelial adenocarcinoma that involves breast andextramammarian tissues. It is often associated with ductal carcinoma in situ and/or invasive ductal cancer.Molecular pathways that play a role in development of Paget’s disease are stil unclear. Expression patterns ofCox-2 and bcl-2 were therefore assessed. Materials and
Methods: Patients with a histopathological diagnosis ofPaget’s disease were included in this study. Patient files were analysed retrospectively.
Results: Invasive cancerwas diagnosed in 35 (76.1%) of the patients, 7 (15.2%) had ductal carcinoma in situ and 4 (8.7%) patients had noassociated neoplasm. Twenty four (52.2%) patients showed COX-2 expression in Paget cells whereas no expressionwas seen in 22 (47.8%) patients. No relation was found between COX-2 expression and the lesion underlyingPaget’s disease (p=0.518). Bcl-2 expression in Paget cells was found positive in 12 (26.1%) and negative in 27(58,7%) cases. There was no relation between Bcl-2 expression and the lesion accompanying Paget’s disease(p=0.412). No relation was observed between COX-2 expression and Bcl-2 expression (p=0.389).
Conclusions:In breast cancer, COX-2 expression is associated with poor prognostic factors. As COX-2 expression increasesthe tendency to metastasize also increases. In our study we found a significantly high COX-2 expression inPaget’s disease of the breast. We suggest that COX-2 expression and inflammatory processes may play a rolein pathogenesis of the Paget’s disease of the breast.