In order to explore the association between cadherin 13 (CDH13) gene promoter methylation and lungcarcinoma (LC) risk, we carried out a meta-analysis with searching of PubMed, Web of Science. Ultimately,17 articles were identified and analysised by STATA 12.0 software. Overall, we found a significant relationshipbetween CDH13 promoter methylation and LC risk (odds ratio=6.98, 95% confidence interval: 4.21-11.56,p<0.001). Subgroup analyses further revealed that LC risk was increased for individuals carrying the methylatedCDH13 compared with those with unmethylated CDH13. Hence, our study identified a strong association betweenCDH13 gene promoter methylation and LC and highlighted a promising potential for CDH13 methylation inLC risk prediction.