Cancer Survivors Aged 40 Years or Elder are Associated with High Risk of Chronic Kidney Disease: The 2010-2012 Korean National Health and Nutrition Examination Survey


Background: The number of cancer survivors is increasing globally and recently, higher rates of comorbiditiesin cancer survivors have been reported. However, no studies have investigated whether cancer survivors havea higher risk of chronic kidney disease (CKD). Accordingly, our study evaluated the association betweencancer survivors and the risk of CKD using the 2010-2012 Korean National Health and Nutrition ExaminationSurvey. Materials and
Methods: A total of 11,407 participants aged 40 years and over were categorized intotwo groups according to cancer experience. Multiple variables were compared and the odds ratios (ORs) forCKD prevalence were calculated using a weighted logistic regression analysis between the two groups.
Results:Cancer survivors were older than were those in the non-cancer group, on average, the percentages of glomerularfiltration rate(GFR) lower than 60mL/min/1.73m2, proteinuria, and CKD were significantly higher in cancersurvivors when compared to controls. Weighted logistic regression analyses demonstrated that cancer survivorshad a higher risk for CKD after adjusting for multiple variables (OR (95% confidence interval), 2.88 (1.48-5.59)).
Conclusions: Our study demonstrated a possible association between CKD and cancer survival in Koreanadults. Identifying and correcting risk factors for cancer survivors would positively affect prevention of CKDand result in a better cancer prognosis.