Thyroid cancer is the most prevalent endocrine cancer and is evident in nearly 5% of thyroid nodules. Thecorrelation between mean platelet volume (MPV) and many other cancer types has been investigated previously.However, the correlation between papillary thyroid carcinoma (PTC) and MPV has not yet been studied in detail.The aim of this study was to examine whether MPV would be a useful inflammatory marker to differentiate PTCpatients from cases of benign goiter and healthy controls. Preoperative MPV levels in patients with PTC werefound to be significantly higher when compared with benign goiter patients and healthy controls ((respectively,8.05 femtoliter (fl), 7.57 fl, 7.36 fl, p=0.001). After surgical treatment of PTC patients, a significant decrease inMPV levels was seen (8.05 fl versus 7.60 fl, p=0.005). ROC analysis suggested 7.81 as the cut-off value for MPV(AUC=0.729, sensitivity 60%, specificity 80%). In conclusion, maybe changes in MPV levels can be used asan easily available biomarker for monitoring the risk of PTC in patients with thyroid nodules, enabling earlydiagnosis of PTC.