Intrinsic Tumour Factors Affecting Recurrence in Non Muscle Invasive Bladder Cancer: a Hospital Based Study from India


Background: Depending on various pathological factors, non muscle invasive bladder cancer (NMIBC) showsvarying degrees of recurrence. The aim of this study was to determine the incidence of recurrence of NMIBSin our centre, study the influence of intrinsic tumour characteristics like grade, stage, size and number, andcompare our results with data in the published literature. Materials and
Methods: A hospital based retrospectivestudy was conducted on patients who underwent treatment for NMIBC from 2011 to 2014. The factors studiedwere number, size, grade, stage and site for correlation with recurrence. Statistical analysis was performedusing Medcalc version 12, using Pearson’s Chi square test to ascertain associations between variables.
Results:A total of 73 patients with NMIBC were studied of which 48 (65.8%) had low grade and 25 (34.2%) had highgrade tumours. Some 38 patients (52.1%) had Ta tumours, 34 (46.6%) had T1 and one had CIS. Mean follow upwas 34.3 months. Recurrence rates were found to be 33.3% in low grade and 52.0% in high grade tumours. Theoverall recurrence rate in our centre was 39.7%. Significant correlations were seen between stage and recurrence,with a rate of 15% for Ta and 63.3% for T1 tumours. Fourteen out of 21 bladder cancers (66.6%) with multipletumours demonstrated recurrence (p=0.006). Grade, size and site had no influence.
Conclusions: In our study,recurrence of NMIBC was found to be directly proportional to stage and number of primary tumours, but notgrade, size and site. The incidence of recurrence of NMIBC both stage wise and grade wise in our centre wasalso low compared to the data in the published literature.