The present investigation was designed to assess the anticancer activity of six different leaf extracts (ethylacetate, methanol, chloroform, petroleum ether, n-butanol, and water soluble) of Abelia triflora on A-549 humanlung adenocarcinoma epithelial cells. A-549 cells were exposed to 10-1000 μg/ml concentrations of the leaf extractsof A. triflorafor 24 h and then percentage cell viability was assessed by 3-(4,5-dimethylthiazol-2yl)-2,5-biphenyltetrazolium bromide (MTT) assay. The results showed that leaf extracts of A. triflora significantly reduced theviability of A-549 cells in a concentration-dependent manner. Decrease was recorded as 31% with ethyl acetate,36% with methanol, 46% with chloroform, 54% with petroleum ether, 62% with n-butanol, and 63% withwater soluble extracts at 1000 μg/ml each. Among the various plant extracts, ethyl acetate extract showed thehighest decrease in the percentage cell viability, followed by methanol, chloroform, petroleum ether, n-butanol,and water soluble extracts. Our results demonstrated preliminary screening of anticancer activity of differentsoluble extracts of A. triflora extracts against A-549 cells, which can be further used for the development of apotential therapeutic anticancer agents.