Purpose: The aim of this study was to investigate the association between preoperative leukocyte and plateletcounts and the stage of the disease in patients with endometrial cancer. Materials and
Methods: Data for 100patients undergoing total abdominal hysterectomy and bilateral salpingoophorectomy for benign uterinediseases and 177 patients surgically staged for endometrial cancer at Ondokuz Mayis University, Department ofGynecology and Obstetrics between 2005 and 2013, with preoperative complete blood count in the week prior tosurgery including WBC, platelet count, pathologic evaluation for both benign and malign endometrium lesions,tumor stage and presence of lymphovascular space invasion (LVI), were retrospectively analyzed.
Results: Thepreoperative leukocyte count was significantly higher in patients with endometrial cancer when compared tothe patients with benign diseases. However, there were no significant differences in platelet counts betweenthe groups. Patients with advanced stage endometrial cancer had higher preoperative leukocyte counts whencompared to the early stage disease whereas there was no difference in platelet count. Multivariate regressionanalysis identified preoperative leukocytosis as an independent prognostic factor for endometrial cancer. Theoptimal cut-off point for WBC was calculated as 10,500 to differentiate stage 1-2-3 and 4 with 88.9% sensitivityand 86.3% specificity (AUC: 0.901, 95% CI: 0.829-0.973, p<0.001, PPV: 25.8%, NPV: 99.3%).
Conclusions:Preoperative leukocytosis is independently associated with advanced endometrial cancer.