MiR-34b/c rs4938723 Polymorphism Significantly Decreases the Risk of Digestive Tract Cancer: Meta-analysis

Background: Previous studies investigating the association between miR-34b/c rs4938723 polymorphism andcancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR-34b/c rs4938723 polymorphism and digestive cancer risk. Materials and
Methods: Literature database includingPubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerningthe association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk.
Results: A total of 6studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysissuggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model,homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CCvs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs TT/TC: OR=0.68, 95%CI=0.58-0.80, p-value=0.000).Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger’s funnel plot andEgger’s test did not show significant publication bias.
Conclusions: The current evidence supports the conclusionthat the miR-34b/c rs4938723 polymorphism decreases an individual’s susceptibility to digestive cancers.