Analysis of Relationships Between Prethrombotic States and Cervical Cancer


Objective: To analyze the relationship between a prethrombotic state and the occurrence of thrombosis, aswell as survival time for patients with cervical cancer.
Methods: Patients with first diagnosis of cervical cancerwere subgrouped according to FIGO staging, and two D-dimer levels were assessed. According to the results,patients are divided into an observation group (abnormal) and control group (normal).
Results: For 106 patientswith cervical cancer, 38 with abnormal D-dimer, the abnormal rate is 35.9%, of which stage Ⅰ accounted for 6.5%,stageⅡ 38.5%, stage Ⅲ 50%, and stage Ⅳ 61.1% (p=0.013); The level of D-dimers in stageⅠ wass 0.87±0.68ug/ml, while in stage Ⅱ it was 1.50±1.35ug/ml, stage Ⅲ 2.60±1.86ug/ml and stage Ⅳ 18.6±53.4ug/ml (P=0.031);after follow-up of patients for 2-30 months, the mortality of observation group is 21.1%, while for control groupit was 2.94% (p <0.01). In the observation group, survival time was 15.1±5.8 months, while for control group itwas 21.0±5.4 months, the difference between two groups being highly significant (p=0.000).
Conclusion: Thereis a direct correlation between prethrombotic state and the grade malignancy of cervical cancer. The level ispositively correlated with clinical stage, and is inversely related to survival time, so that a prethrombotic statecould be used to predict the prognosis for patients with cervical cancer.