Differences in Prognostic Factors between Early and Late Recurrence Breast Cancers


Background: Breast cancer (BC) is the most frequent malignancy among females and is a leading cause ofdeath of middle-aged women. Herein, we evaluated baseline characteristics for BC patients and also comparedthese variables across ealry and late recurrence groups. Materials and
Methods: Between 1995 to 2014, amongfemale breast cancer patients referred to our oncology clinic, eighty-six were entered into our study. All haddistant metastasis. Early recurrence was defined as initial recurrence within 5 years following curative surgeryirrespective of site. Likewise, late recurrence was defined as initial recurrence after 5 years. No recurrence wasdefined for survivors to a complete minimum of 10 years follow-up. Significant prognostic factors associatedwith early or late recurrence were selected according to the Akaike Information Criterion.
Results: The medianfollow-up was 9 years (range, 1-18 years). During follow-up period, 51 recurrences occurred (distant metastasis),31 early and 20 late. According to the site of recurrence, there were 51 distant. In this follow-up period, 19patients died. Compared with the early recurrence group, the no recurrence group had lower lymph nodeinvolvement and more p53 positive lesions but the late recurrence group had lower tumor size. In comparisonto no recurrence, p53 (odds ratio [OR] 6.94, 95% CI 1.49-32.16) was a significant prognostic factor for earlyrecurrence within 5 years.
Conclusions: Tumor size, p53 and LN metastasis are the most important risk factorsfor distance recurrence especially in early recurrence and also between of them, p53 is significant prognosticfactor for early recurrence.