Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis


Background: Helicobacter pylori plays an important role in gastric cancer, which has a relatively low inciduencein Thailand. MDM2 is a major negative regulator of p53, the key tumor suppressor involved in tumorigenesis ofthe majority of human cancers. Whether its expression might explain the relative lack of gastric cancer in Thailandwas assessed here. Materials and
Methods: This single-center study was conducted in the northeast region ofThailand. Gastric mucosa from 100 patients with Helicobacter pylori associated gastritis was analyzed for MDM2SNP309 using real-time PCR hybridization (light-cycler) probes.
Results: In the total 100 Helicobacter pyloriassociated gastritis cases the incidence of SNP 309 T/T homozygous was 78 % with SNP309 G/T heterozygousfound in 19% and SNP309 G/G homozygous in 3%. The result show SNP 309 T/T and SNP 309 G/T to be rathercommon in the Thai population.
Conclusions: Our study indicates that the MDM2 SNP309 G/G homozygousgenotype might be a risk factor for gastric cancer in Thailand and the fact that it is infrequent could explain tosome extent the low incidence of gastric cancer in the Thai population.