Potential Role of Electrochemotherapy as Anticancer Treatment for Cutaneous and Subcutaneous Lesions


Department of Radiology, Radiotherapy Unit, Aretaieion University Hospital, Medical School, Kapodistrian University of Athens, Greece


Background The aim of this study was to investigate whether electrochemotherapy is a clinically and cost- effective treatment option against skin tumors. Materials and Methods We performed an analysis of the current literature based on database searches in PubMed/MEDLINE and we included articles till July 2012. Terms used for the search were 'electrochemotherapy', 'skin cancer', 'recurrence', and 'cutaneous and subcutaneous tumors'. Only papers published in English were included. In addition, we performed an analysis of the cost effectiveness of the method. Results The combination of physics and chemistry is the foundation for electrochemotherapy and its ef cacy, independent of the tumor histology. Clinical data showed that ECT is well tolerated and can be used in dif cult cases without other available treatment options. The analysis also showed that the treatment is feasible and cost-effective. Conclusions Electrochemotherapy is a clinically ef cient safe and cost-effective treatment and clinicians should not hesitate to use it as alternative therapeutic modality or as palliative treatment.