Key laboratory of diseases of urological system Gansu Province, Gansu Nephro-Urological Clinical Center, The Second Hospital of Lanzhou University, Lanzhou, China
Background To investigate the association circumcision with prostate cancer. Materials and Methods We searched PubMed, EMBASE, the Cochrane Library, and Chinese biomedicine literature database up to August 2015. All case-control studies were identi ed in which investigated the association circumcision with prostate cancer. Three authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.3 and STATA version 11.0. Results Six case-control studies met the inclusion criteria. The pooled meta-analysis showed that there was a lower incidence of circumcision in prostate cancer patients compared with control (OR0.90, 95% con dence interval [CI] 0.82-0.98, P0.01). The results of meta-analysis also showed that no signi cant difference was found between circumcision and less aggressive prostate cancer (OR0.93, 95% CI 0.83-1.04, P0.19); however, there was a lower incidence of circumcision in more aggressive prostate cancer compared with control (OR 0.84, 95% CI 0.72-0.97, P0.02). The Egger's results did not show any evidence of publication bias(P0.798). Conclusions In summary, within the limits of available data, male with circumcision appears to have a lower incidence of prostate cancer. In the future, high-quality multicenter studies are needed to thoroughly verify the outcome.