Clinico-Hematological Findings for Classical Hodgkin's Lymphoma an Institutional Experience


Department of Hematology & Blood bank, Liaquat National Hospital and Medical College, Karachi, Pakistan


Background Classical Hodgkin's lymphoma (cHL) is a B-cell lymphoid neoplasm characterized by a distinctive biological behavior with potentially curable disease characteristics. It is an uncommon hematological malignancy which primarily affects younger individuals. The rationale of this study was to determine its clinico-hematological pro le along with stage strati cation in Pakistani patients. Materials and Methods In this descriptive study, adult patients with Hodgkin's lymphoma were enrolled from January 2010 to December 2014. Results Sixty two histopathologically con rmed cases of cHL were identi ed. There were 42 males and 20 females, with a male to female ratio of 2 1. The mean age was 29.713.8 years with the median age of 30 years. B symptoms were present in 72.5% of patients. Histopathologically, the mixed cellularity type constituted 62.9% of cases, followed by nodular sclerosis in 25.8%, lymphocyte predominant in 9.6% and lymphocyte depleted in 1.6%. Stages I and II were present in 43.5% of patients at disease presentation, with 56.4% in stages III and IV. Conclusions Our analysis shows that clinico-pathological features of Hodgkin's lymphoma in Pakistan are comparable to published data. Mixed cellularity is the commonest histological variant and advanced stage at presentation are common ndings in our patients.