Association between Pax8-PPARandgamma;1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis


Undergraduate of School of Public Health, Hebei Medical University, China


Background: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-PPAR1) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- PPAr1 rearrangement. In order to have a better understanding of the association between Pax8-PPAR1 rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. Materials and Methods: The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a fixed-effects model. We also performed heterogeneity and publication bias analyses. Results: Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-PPAR1 rearrangement was significantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-PPAR1 rearrangement and follicular thyroid cancer was 6.04 (95%CI 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI 4.86-20.5) in the RT-PCR. Conclusions: The final results demonstrated that Pax8-PPAR1 rearrangement has significant association with follicular thyroid cancer.