Dosimetric Comparison between Intensity Modulated Radiotherapy and 3 Dimensional Conformal Radiotherapy in the Treatment of Rectal Cancer

Document Type: Research Articles

Authors

1 SENIOR RESIDENT DEPARTMENT OF RADIATION ONCOLOGY ACTION CANCER HOSPITAL, PASCHIM VIHAR DELHI

2 Consultant Department of Radiation Oncology Rajiv Gandhi Cancer Institute and research centre,Delhi.

3 Associate consultant Department of Radiation Oncology Action Cancer Hospital Paschim vihar, Delhi, India

4 Consultant, Rajiv Gandhi Cancer Institute and research centre Delhi, india

5 Chief Medical Physicist, Rajiv Gandhi Cancer Institute and research centre Delhi, india

6 Medical Physicist, Rajiv Gandhi Cancer Institute and research centre Delhi, india

Abstract

 
Objective: To compare dosimetric parameters of 3 dimensional conformal radiotherapy (3 DCRT) and intensity modulated radiotherapy (IMRT) in terms of target coverage and doses to organs at risk (OAR) in the management of rectal carcinoma. Methods: In this prospective study, conducted between August 2014 and March 2016, all patients underwent CT simulation along with a bladder protocol and target contouring according to the Radiation Therapy Oncology Group (RTOG) guidelines. Two plans were made for each patient (3 DCRT and IMRT) for comparison of target coverage and OAR. Result: A total of 43 patients were recruited into this study. While there were no significant differences in mean Planning Target Volume (PTV) D95% and mean PTV D98% between 3 DCRT and IMRT, mean PTV D2% and mean PTV D50% were significantly higher in 3 DCRT plans. Compared to IMRT, 3 DCRT resulted in significantly higher volumes of hot spots, lower volumes of cold spots, and higher doses to the entire OAR. Conclusion: This study demonstrated that IMRT achieves superior normal tissue avoidance (bladder and bowel) compared to 3 DCRT, with comparable target dose coverage.

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