sanchez, C., camus, M., medina, L., oddo, D., artigas, R., perez, A., dominguez, F., razmilic, D., Navarro, M., galindo, H., acevedo, F. (2016). Clinico-Pathologic Subtypes of Breast Cancer Primary Tumors Are Related to Prognosis after Recurrence. Asian Pacific Journal of Cancer Prevention, 17(12), 5081-5086. doi: 10.22034/APJCP.2016.17.12.5081
cesar sanchez; mauricio camus; lidia medina; david oddo; rocio artigas; alejandra perez; francisco dominguez; dravna razmilic; Maria Elena Navarro; hector galindo; francisco acevedo. "Clinico-Pathologic Subtypes of Breast Cancer Primary Tumors Are Related to Prognosis after Recurrence". Asian Pacific Journal of Cancer Prevention, 17, 12, 2016, 5081-5086. doi: 10.22034/APJCP.2016.17.12.5081
sanchez, C., camus, M., medina, L., oddo, D., artigas, R., perez, A., dominguez, F., razmilic, D., Navarro, M., galindo, H., acevedo, F. (2016). 'Clinico-Pathologic Subtypes of Breast Cancer Primary Tumors Are Related to Prognosis after Recurrence', Asian Pacific Journal of Cancer Prevention, 17(12), pp. 5081-5086. doi: 10.22034/APJCP.2016.17.12.5081
sanchez, C., camus, M., medina, L., oddo, D., artigas, R., perez, A., dominguez, F., razmilic, D., Navarro, M., galindo, H., acevedo, F. Clinico-Pathologic Subtypes of Breast Cancer Primary Tumors Are Related to Prognosis after Recurrence. Asian Pacific Journal of Cancer Prevention, 2016; 17(12): 5081-5086. doi: 10.22034/APJCP.2016.17.12.5081
Clinico-Pathologic Subtypes of Breast Cancer Primary Tumors Are Related to Prognosis after Recurrence
2Department of Surgery, School of Medicine Pontificia Universidad Catolica de Chile, Santiago, Chile
3Department of Hematology-Oncology, School of Medicine Pontificia Universidad Catolica de Chile, Santiago, Chile
4Department of Pathology, School of Medicine Pontificia Universidad Catolica de Chile, Santiago, Chile
5Pontificia Universidad Catolica de Chile, Santiago, Chile
6Department of Hematology-Oncology, School of Medicine Pontificia Universidad Catolica de Chile, Santiago, Chile
7Department of Radiology, School of Medicine Pontificia Universidad Catolica de Chile, Santiago, Chile
Receive Date: 05 October 2016,
Revise Date: 16 December 2016,
Accept Date: 16 January 2017
Abstract
Background: Pathological factors, based mainly on immunohistochemistry (IHC) and histological differentiation, are mostly used to differentiate breast cancer (BC) subtypes. Our present aim was to describe the characteristics and survival of a relapsing BC patient cohort based on clinico-pathologic subtypes determined for the primary tumors. Methods: We used a clinico- pathological definition of BC subtypes based on histological grade (HG), estrogen receptor (ER), progesterone receptor (PgR),and epidermal growth factor receptor type 2 (HER2) expression assessed by IHC. We determined variables associated with loco-regional recurrence (LRR), second primaries (SP), systemic recurrence (SR) and post-recurrence survival (PRS). Results: Out of 1,702 patients, 240 (14%) had an event defined as recurrence. Those with recurrent disease were significantly younger than those without,and were initially diagnosed at more advanced stages, with larger tumors, greater lymph nodal involvement and higher HG. With a median follow up of 61 months (1-250), 4.6% of patients without recurrence and 56.6% of patients with an event defined as recurrence had died. The median PRS for the LRR group was 77 months; 75 months for those who developed a SP and 22 months for patients with an SR (p <0.0001). In SR cases, the median PRS was shorter for ER- tumors than for ER+ tumors (15 vs. 26 months, respectively; p = 0.0019, HR 0.44; CI: 0.25-0.44). Conclusions: Subtype, defined through classic histopathologic parameters determined for primary tumors, was found to eb related to type of recurrence and also to prognosis after relapse.
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