Lack of Altered BECN1 Gene Expression in Iranian Patients with Acute Myeloid Leukemia

Document Type: Research Articles

Authors

1 department of Genetic,South PNU Centre,payame noor university,Tehran,Iran

2 department of Genetics and Biotechnology, Payame Noor University, Tehran, Iran

3 Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

4 Department of Medical Genetics, Shohada Cancer Research Center, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

5 Department of Molecular Genetics,Tehran Medical Sciences Branch, Islamic Azad University,Tehran Iran.

6 - Proteomics Research Center School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran Iran.

7 Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

8 Department of Periodontics, Phytochemistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.

9 Department of Pharmacology, Phytochemistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.

10 AJA Cancer Research Center (ACRC), AJA University of Medical Sciences, Tehran, Iran.

11 Shahid Beheshti University of Medical Sciences

Abstract

 
Acute myeloid leukemia (AML), one of the most prevalent leukemia types in adults, demonstrates great heterogeneity in molecular and clinical terms. Hence, there is a necessity to the mechanisms involved in AML generation in order to determine optimal treatment. This cross sectional study aimed to assess changes in BECN1 gene expression in with blood samples from 30 AML patients, compared with samples from 15 healthy persons. RNA was extracted and cDNA was synthesized and Real Time PCR applied to determine BECN1 gene expression. The results showed no significant differences in BECN1 gene expression between patients with AML and normal controls (P > 0.05). It appears that expression of BECN1 does not play a significant role in genesis of AML leukemia.

Keywords