1department of Genetic,South PNU Centre,payame noor university,Tehran,Iran
2department of Genetics and Biotechnology, Payame Noor University, Tehran, Iran
3Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
4Department of Medical Genetics, Shohada Cancer Research Center, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
5Department of Molecular Genetics,Tehran Medical Sciences Branch, Islamic Azad University,Tehran Iran.
6- Proteomics Research Center School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran Iran.
7Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
8Department of Periodontics, Phytochemistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.
9Department of Pharmacology, Phytochemistry Research Center, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran.
10Shahid Beheshti University of Medical Sciences
Acute myeloid leukemia (AML), one of the most prevalent leukemia types in adults, demonstrates great heterogeneity in molecular and clinical terms. Hence, there is a necessity to the mechanisms involved in AML generation in order to determine optimal treatment. This cross sectional study aimed to assess changes in BECN1 gene expression in with blood samples from 30 AML patients, compared with samples from 15 healthy persons. RNA was extracted and cDNA was synthesized and Real Time PCR applied to determine BECN1 gene expression. The results showed no significant differences in BECN1 gene expression between patients with AML and normal controls (P > 0.05). It appears that expression of BECN1 does not play a significant role in genesis of AML leukemia.