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Asian Pacific Journal of Cancer Prevention
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Gholizade-Tobnagh, S., Bakhti, S., Latifi-navid, S., zahri, S., Bakhti, F. (2017). Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) Diseases. Asian Pacific Journal of Cancer Prevention, 18(1), 43-49. doi: 10.22034/APJCP.2017.18.1.43
Shokufe Gholizade-Tobnagh; Seyedeh Zahra Bakhti; saeid Latifi-navid; saber zahri; fatemeh Sadat Bakhti. "Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) Diseases". Asian Pacific Journal of Cancer Prevention, 18, 1, 2017, 43-49. doi: 10.22034/APJCP.2017.18.1.43
Gholizade-Tobnagh, S., Bakhti, S., Latifi-navid, S., zahri, S., Bakhti, F. (2017). 'Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) Diseases', Asian Pacific Journal of Cancer Prevention, 18(1), pp. 43-49. doi: 10.22034/APJCP.2017.18.1.43
Gholizade-Tobnagh, S., Bakhti, S., Latifi-navid, S., zahri, S., Bakhti, F. Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) Diseases. Asian Pacific Journal of Cancer Prevention, 2017; 18(1): 43-49. doi: 10.22034/APJCP.2017.18.1.43

Role of Plasticity Region Genes and cagE gene of cagPAI of Helicobacter pylori in Development of Gastrointestinal (GI) Diseases

Article 8, Volume 18, Issue 1, January 2017, Page 43-49  XML PDF (382.41 K)
Document Type: Research Articles
DOI: 10.22034/APJCP.2017.18.1.43
Authors
Shokufe Gholizade-Tobnagh email 1; Seyedeh Zahra Bakhti1; saeid Latifi-navid1; saber zahri1; fatemeh Sadat Bakhti2
1Department of Biology, Faculty of Sciences, University of MohagheghArdabili, Ardabil
2Department of Biostatistics, Faculty of Public Health, Mazandaran University of Medical Sciences, Sari, Iran
Receive Date: 14 September 2016,  Revise Date: 13 January 2017,  Accept Date: 05 February 2017 
Abstract
 
Background: Helicobacter pylori is a Gram-negative, micro aerophilic bacterium in the human stomach that is associated with the development of gastrointestinal ailments such as peptic ulcer (PU) and gastric cancer (GC). In the present study, plasticity region genes (jhp0940, jhp0945 and jhp0947) and and cagE gene of cagPAI were assessed independently and in combination for their ability to predict clinical consequences. Materials and Methods: A total of 211 strains which were isolated from patients with different gastrointestinal diseases (114 with non-atrophic gastritis, 59 with PU, and 38 with GC) were genotyped by PCR and sequencing. Data were collected and analyzed using SPSS software version 19. Logistic regression models were applied to determine relationships between the plasticity region genes and cagE of H.pylori and clinical status. Results: The cagE gene (71.1%) had the highest frequency and jhp0945 (13.7%) was the least abundant among the genes examined. The jhp0940 gene was significantly associated with GC (P = 0.0007), but not PU. On multiple logistic regression analysis, adjusted for both age and sex, the jhp0940 genotype was significantly associated with GC (odds ratio, OR = 2.8, 95%CI = 1.1–7.0; P = 0.027). The jhp0940+/ jhp0945+/ jhp0947+genotype was also linked to an increased risk of GC (OR = 50.4, 95%CI = 5.1–500.0; P = 0.0008) while no genotype correlation was found with PU in Iran (P > 0.05). Conclusions: Given the high frequency of cagE, this gene could be a suitable marker for the presence of cagPAI in Iranian strains. The jhp0940 genotype could also be a strong predictor of GC in Iran.
Keywords
Helicobacter pylori; plasticity region genes; cagE; gastrointestinal diseases; Iran
Main Subjects
Cancer biology
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